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Manchester United vs Chelsea Prediction, Preview, Team News and Lineups 20.09.2025

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Who Will Win This Match?

Manchester UnitedChelsea
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All Competitions
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LAST GAME: Manchester City 3 - 0 Manchester United
  • Premier League
  • Sep 14, 2025 at 3:31 pm
  • Etihad Stadium
LAST GAME: Bayern Munich 3 - 1 Chelsea
  • Champions League
  • Sep 17, 2025 at 7:01 pm
  • Allianz Arena
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Event Details

  • Date and Time: Saturday, September 20, 2025, 12:30 PM EDT
  • Venue: Old Trafford, Manchester, England
  • Competition: Premier League
Odds via 20Bet
Manchester United vs ChelseaSaturday, September 20, 2025, 12:30 PM EDT
Manchester United Odds+173
Chelsea Odds+143
Draw+262
Over 2.5-164
Betting BonusUp to 100 $/€

Manchester United vs Chelsea Preview and Team News

Manchester United Team News

The pressure is back on Ruben Amorim ahead of Manchester United’s encounter with Chelsea this weekend. Despite eye-catching performances in their opening two league matches, similar problems to last season have quickly re-emerged in the 3-4-2-1 formation. 

The Red Devils looked weak in the middle of the field in last weekend’s 3-0 defeat to Manchester City, and they were made to pay for costly defensive errors. Amorim once again faced questions about his tactics, but the Portuguese insisted that he isn’t going to change his approach. 

Bruno Fernandes could be shifted into his preferred No. 10 role this weekend, with Amad Diallo put into a wing-back position. Kobbie Mainoo could be handed a start after impressing in the derby defeat against City. 

Manchester United predicted lineup vs Chelsea (3-4-2-1): Lammens; Yoro, Maguire, Shaw; Diallo, Mainoo, Ugarte, Dorgu; Fernandes, Mbeumo; Sesko.

Chelsea Team News

Enzo Maresca cut a frustrated figure following Chelsea’s latest outing, as the Blues threw away a 2-1 advantage in the closing stages. The team controlled the game, but were forced to remain patient to create their openings. 

Maresca’s side dominated possession, with Caicedo and Fernandez working excellently in the middle of the park. Palmer also looked back to his best from the bench, netting in the 2-2 draw against Brentford

Maresca will have options in the wide areas this weekend, and Gittens could be preferred to former United star Alejandro Garnacho on the left. 

Chelsea predicted lineup vs Manchester United (4-2-3-1): Sanchez; James, Fofana, Chalobah, Cucurella; Caicedo, Fernandez; Neto, Palmer, Gittens; Pedro.

Manchester United vs Chelsea Prediction 

  • Pick: The Draw
  • Odds: +262 (20Bet)
  • Correct score prediction: Manchester United 1-1 Chelsea

There will be huge pressure on Amorim and his Man United side this weekend, and a repeat defeat from last Sunday could leave the Portuguese fighting for his future at Old Trafford. 

Despite the defeat, United still showed flashes of offensive quality at the Etihad and were only denied by moments of magic from the Man City goalkeeper. Defensively, Amorim’s men will need to improve this weekend, and their vulnerability from set pieces would be a concern against Chelsea. 

However, draws are a prevalent outcome when these clubs collide, with seven of the last 12 meetings ending level at Old Trafford. A point will likely be seen as a positive by both managers.

Manchester United vs Chelsea Prediction, Betting Tip

  • Pick: Both Teams to Score
  • Odds: -204 (20Bet)

Both Manchester United and Chelsea have shown glimpses of their best attacking quality this season, with the former ranking among the Premier League’s top sides in expected goals (xG). However, both have also struggled to be clinical in front of goal. 

With that in mind, while we can foresee both teams scoring on Saturday, it’s also likely that under 2.5 goals will be a popular selection. 

Manchester United vs Chelsea Where to Watch (USA, Canada) 

  • NBC (USA)
  • FuboTV (Canada)

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