| Liverpool wins | Draw | Southampton wins |
|---|---|---|
| 1.165 | 7.9 | 14.5 |
| Liverpool | Southampton |
|---|---|
All Competitions
| All Competitions
|
LAST GAME: Liverpool 2 - 1 Everton
| LAST GAME: Hull City 3 - 1 Southampton
|
Event Details
- Date and Time: Tuesday, September 23, 2025, 3:00 PM EDT
- Venue: Anfield, Liverpool, England
- Competition: EFL Cup
| Odds via 20Bet | |
| Liverpool vs Southampton | Tuesday, September 23, 2025, 3:00 PM EDT |
| Liverpool Odds | -625 |
| Southampton Odds | +1400 |
| Draw | +690 |
| Over 2.5 | -323 |
| Betting Bonus | Up to 100 $/€ |
Liverpool vs Southampton Preview and Team News
Liverpool Team News
Arne Slot’s Liverpool are among the favorites to win the EFL Cup this season. The reigning Premier League champions have started the new campaign in excellent form, winning all six of their matches across all competitions. Confidence must be high after a 2-1 success against Everton on Saturday.
The Reds have continued to deploy the 4-2-3-1 system, with Gravenberch and Mac Allister playing the crucial holding roles. However, with big games coming up in both the Premier League and Champions League, Slot will likely rotate his squad for this week’s clash.
Reserve goalkeeper Mamardashvili could be handed a first competitive start for the club. Meanwhile, Gomez, Ngumoha, and Robertson are all expected to see minutes.
Liverpool predicted lineup vs Southampton (4-2-3-1): Mamardashvili; Bradley, Konate, Gomez, Robertson; Jones, Endo; Chiesa, Wirtz, Ngumoha; Isak.
Southampton Team News
Will Still’s main challenge this season is guiding Southampton back into the Premier League. However, it’s been a slow start to the campaign under the new head coach, with just one win in their first six Championship fixtures.
The Saints have also gone winless in their last five and suffered defeats in two of their previous four. Still has stuck with the 4-2-3-1 formation, but rotation seems likely after a disappointing 3-1 defeat to Hull City last weekend.
Adam Armstrong and Ross Stewart could both be recalled after coming off the bench on Saturday. Meanwhile, reserve goalkeeper Alex McCarthy is also expected to feature.
Southampton predicted lineup vs Liverpool (4-2-3-1): McCarthy; Roerslev, Harwood-Bellis, Stephens, Manning; Downes, Charles; Fellows, Stewart, Fraser; Armstrong.
Liverpool vs Southampton Prediction
- Pick: Liverpool
- Odds: -625 (20Bet)
- Correct score prediction: Liverpool 3-0 Southampton
This should be a straightforward assignment for Slot’s in-form champions. Liverpool have already been dominant in the attacking areas this season, and even with rotation, they’ll still field proven international stars on Tuesday.
New signings Wirtz and Isak should view this tie as a perfect opportunity to get their form on track for the club, and both could have their hands in goals against a struggling Championship opponent.
Liverpool vs Southampton Prediction, Betting Tip
- Pick: Over 2.5 Goals
- Odds: -323 (20Bet)
Over 2.5 goals stands out as the best bet for Tuesday’s clash. Each of the last six head-to-head meetings has seen this benchmark breached, and given Southampton’s form, it’s hard to see them turning things around at Anfield.
Liverpool’s matches are averaging 3.2 goals per 90 minutes this season, and they’ve netted 2.2 goals per game in the Premier League. Meanwhile, the Saints have underperformed defensively in 2025-26, conceding two goals per outing on the road from an xGA of 1.20.
Liverpool vs Southampton Where to Watch (USA, Canada)
- CBS (USA)
- DAZN (Canada)
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